GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338199/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338199GEOGSEfalseCannabidiol reverses neuroimmune priming in aged Gulf War Illness miceGulf War Illness (GWI) affects up to one-third of 1990–1991 Gulf War veterans and is associated with chronic low-grade neuroinflammation, yet its cellular substrates remain unclear and targeted pharmacological therapies are still limited. By using bulk RNA-seq analyses of whole-brain in an established GWI mouse model, we uncovered a multi-lineage primed neuroimmune signature in aged GWI mice. Systemic lipopolysaccharide (LPS) elicited an amplified pro-inflammatory response in the brains of GWI mice compared to age-matched controls. Chronic cannabidiol (CBD) attenuated neuroimmune priming at baseline, and suppressed the parenchymal hyper-response, defining a therapeutic axis amenable to pharmacological intervention.2026/07/14GSE338199GSM9869156GSM9869145GSM9869144GSM9869155GSM9869154GSM9869165GSM9869164GSM9869153GSM9869152GSM9869163GSM9869151GSM9869162GSM9869161GSM9869150GSM9869160GSM9869149GSM9869159GSM9869148GSM9869158GSM9869147GSM9869146GSM986915724247338199Mus musculus