GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338233/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338233GEOGSEfalseTranscriptomic profiling of MIA PaCa-2 cells treated with hydroxyprogesterone caproatePancreatic ductal adenocarcinoma (PDAC) remains refractory to targeted therapy. This RNA-sequencing study characterizes transcriptional changes in the human PDAC cell line MIA PaCa-2 following treatment with hydroxyprogesterone caproate (HPC). Comparison with DMSO vehicle-treated cells was used to identify HPC-responsive genes and pathways. The transcriptomic analysis supported repression of cell-cycle, DNA-replication and pyrimidine-metabolism programs and contributed to investigation of the COP1-CEBPB-CDA mechanism underlying the anti-PDAC activity of HPC.2026/07/11GSE338233GSM9869673GSM9869672GSM9869671GSM9869670GSM9869679GSM9869678GSM9869677GSM9869676GSM9869675GSM986967424676338233Homo sapiens