{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338380/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338380"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Hepatocyte angiotensinogen deletion protects against Western diet-induced adiposity and hepatic steatosis under thermoneutral housing","description":"Room-temperature housing imposes adaptive cold stress in mice and can alter brown adipose tissue activity and systemic energy expenditure. This study tested whether hepatocyte-specific Agt deletion protects against Western diet-induced metabolic dysfunction under thermoneutral housing. Male hepAGT-/- and hepAGT+/+ littermate mice were housed at room temperature or thermoneutrality and fed a Western diet for 12 weeks. Liver, brown adipose tissue, and epididymal white adipose tissue were collected for bulk RNA-seq to define tissue-specific transcriptional programs associated with hepatocyte angiotensinogen deletion and thermal environment.","dates":{"publication":"2026/08/05"},"accession":"GSE338380","cross_references":{"GSM":["GSM9872500","GSM9872489","GSM9872467","GSM9872468","GSM9872501","GSM9872465","GSM9872487","GSM9872488","GSM9872466","GSM9872504","GSM9872505","GSM9872502","GSM9872469","GSM9872503","GSM9872481","GSM9872482","GSM9872480","GSM9872485","GSM9872463","GSM9872486","GSM9872464","GSM9872483","GSM9872461","GSM9872462","GSM9872484","GSM9872478","GSM9872479","GSM9872476","GSM9872498","GSM9872499","GSM9872477","GSM9872492","GSM9872470","GSM9872471","GSM9872493","GSM9872490","GSM9872491","GSM9872496","GSM9872474","GSM9872497","GSM9872475","GSM9872494","GSM9872472","GSM9872495","GSM9872473","GSM9872508","GSM9872506","GSM9872507"],"GPL":["24247"],"GSE":["338380"],"taxon":["Mus musculus"]}}