GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338380/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338380GEOGSEfalseHepatocyte angiotensinogen deletion protects against Western diet-induced adiposity and hepatic steatosis under thermoneutral housingRoom-temperature housing imposes adaptive cold stress in mice and can alter brown adipose tissue activity and systemic energy expenditure. This study tested whether hepatocyte-specific Agt deletion protects against Western diet-induced metabolic dysfunction under thermoneutral housing. Male hepAGT-/- and hepAGT+/+ littermate mice were housed at room temperature or thermoneutrality and fed a Western diet for 12 weeks. Liver, brown adipose tissue, and epididymal white adipose tissue were collected for bulk RNA-seq to define tissue-specific transcriptional programs associated with hepatocyte angiotensinogen deletion and thermal environment.2026/08/05GSE338380GSM9872500GSM9872489GSM9872467GSM9872468GSM9872501GSM9872465GSM9872487GSM9872488GSM9872466GSM9872504GSM9872505GSM9872502GSM9872469GSM9872503GSM9872481GSM9872482GSM9872480GSM9872485GSM9872463GSM9872486GSM9872464GSM9872483GSM9872461GSM9872462GSM9872484GSM9872478GSM9872479GSM9872476GSM9872498GSM9872499GSM9872477GSM9872492GSM9872470GSM9872471GSM9872493GSM9872490GSM9872491GSM9872496GSM9872474GSM9872497GSM9872475GSM9872494GSM9872472GSM9872495GSM9872473GSM9872508GSM9872506GSM987250724247338380Mus musculus