GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338699/primary200OKTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338699GEOGSEfalseHelicobacter pylori infection-induced succinate accumulation drives IBS-D via KAT2A-mediated H3K79 succinylationTo explore the molecular mechanisms underlying Helicobacter pylori (Hp)-induced diarrhea-predominant irritable bowel syndrome (IBS-D), C57BL/6 mice were allocated into normal control (NC), Hp-infected, and succinate-treated (SA) groups. Alterations in colonic motility and visceral hypersensitivity were then assessed. Comparative RNA-sequencing (RNA-seq) of colonic tissues was performed to identify differentially expressed genes and elucidate the downstream molecular effectors mediating luminal succinate-driven dysmotility2026/09/03GSE338699GSM9880241GSM9880240GSM9880239GSM9880238GSM9880237GSM9880236GSM9880244GSM9880243GSM988024221103338699Mus musculus