{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338745/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome variation profiling by SNP array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338745"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Genome instability induced by Cyclin E overexpression and ionizing radiation in WT and RECQL4-deficient U2OS cells","description":"RECQL4 is a RecQ helicase implicated in DNA replication and genome maintenance. To investigate the effects of RECQL4 deficiency on genome instability induced by replication stress, genome-wide copy number alterations were analyzed using the Affymetrix CytoScan HD Array in WT and RECQL4-deficient U2OS cells with or without Cyclin E overexpression and/or ionizing radiation. Genome-wide copy number alterations were analyzed using the Affymetrix CytoScan HD Array. Raw CEL files are provided together with processed CYCHP files generated using Chromosome Analysis Suite (ChAS) version 4.5.","dates":{"publication":"2026/07/20"},"accession":"GSE338745","cross_references":{"GSM":["GSM9880818","GSM9880817","GSM9880816","GSM9880815","GSM9880824","GSM9880823","GSM9880822","GSM9880821","GSM9880820","GSM9880819"],"GPL":["16131"],"GSE":["338745"],"taxon":["Homo sapiens"]}}