GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338745/primary200OKGenomicsHomo sapiensGenome variation profiling by SNP arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338745GEOGSEfalseGenome instability induced by Cyclin E overexpression and ionizing radiation in WT and RECQL4-deficient U2OS cellsRECQL4 is a RecQ helicase implicated in DNA replication and genome maintenance. To investigate the effects of RECQL4 deficiency on genome instability induced by replication stress, genome-wide copy number alterations were analyzed using the Affymetrix CytoScan HD Array in WT and RECQL4-deficient U2OS cells with or without Cyclin E overexpression and/or ionizing radiation. Genome-wide copy number alterations were analyzed using the Affymetrix CytoScan HD Array. Raw CEL files are provided together with processed CYCHP files generated using Chromosome Analysis Suite (ChAS) version 4.5.2026/07/20GSE338745GSM9880818GSM9880817GSM9880816GSM9880815GSM9880824GSM9880823GSM9880822GSM9880821GSM9880820GSM988081916131338745Homo sapiens