GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338775/primary200OKTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338775GEOGSEfalseThe Histone Demethylase KDM6B Restrains Hypermetabolic LYVE1+ Perivascular Macrophages and Preserves Adipogenic Balance [scRNA-Seq]We employed single-cell RNA sequencing to study adipose tissue macrophages isolated from epididymal white adipose tissue of wild-type and macrophage-specific KDM6B knockout mice fed a high-fat diet for 5 weeks. This study was designed to identify macrophage subpopulations and genotype-dependent transcriptional changes associated with KDM6B deficiency during early diet-induced obesity. These data provide insights into macrophage heterogeneity, inflammatory activation, lipid-associated macrophage states, and immune remodeling in obese adipose tissue.2026/09/01GSE338775GSM9881329GSM9881328GSM9881339GSM9881341GSM9881330GSM9881340GSM9881338GSM9881337GSM9881336GSM9881335GSM9881334GSM9881333GSM9881343GSM9881332GSM9881331GSM988134221103338775Mus musculus