{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338875/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338875"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The Histone Demethylase KDM6B Restrains Hypermetabolic LYVE1+ Perivascular Macrophages and Preserves Adipogenic Balance [RNA-seq wat]","description":"We employed a bulk RNA sequencing approach to study transcriptional remodeling of white adipose tissue in wild-type and macrophage-specific KDM6B knockout mice fed a high-fat diet for 5 weeks. Subcutaneous white adipose tissue and epididymal white adipose tissue were collected and analyzed, with three biological replicates per group. This study was designed to identify depot-specific and genotype-dependent gene expression changes associated with diet-induced obesity. These data provide insights into macrophage-dependent regulation of adipose tissue inflammation, metabolic dysfunction, extracellular matrix remodeling, and tissue adaptation during chronic high-fat diet feeding.","dates":{"publication":"2026/09/01"},"accession":"GSE338875","cross_references":{"GSM":["GSM9883960","GSM9883961","GSM9883962","GSM9883963","GSM9883964","GSM9883965","GSM9883954","GSM9883955","GSM9883956","GSM9883957","GSM9883958","GSM9883959"],"GPL":["24247"],"GSE":["338875"],"taxon":["Mus musculus"]}}