GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338875/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338875GEOGSEfalseThe Histone Demethylase KDM6B Restrains Hypermetabolic LYVE1+ Perivascular Macrophages and Preserves Adipogenic Balance [RNA-seq wat]We employed a bulk RNA sequencing approach to study transcriptional remodeling of white adipose tissue in wild-type and macrophage-specific KDM6B knockout mice fed a high-fat diet for 5 weeks. Subcutaneous white adipose tissue and epididymal white adipose tissue were collected and analyzed, with three biological replicates per group. This study was designed to identify depot-specific and genotype-dependent gene expression changes associated with diet-induced obesity. These data provide insights into macrophage-dependent regulation of adipose tissue inflammation, metabolic dysfunction, extracellular matrix remodeling, and tissue adaptation during chronic high-fat diet feeding.2026/09/01GSE338875GSM9883960GSM9883961GSM9883962GSM9883963GSM9883964GSM9883965GSM9883954GSM9883955GSM9883956GSM9883957GSM9883958GSM988395924247338875Mus musculus