{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338876/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Mus musculus"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338876"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The Histone Demethylase KDM6B Restrains Hypermetabolic LYVE1+ Perivascular Macrophages and Preserves Adipogenic Balance [ATAC-seq pvm]","description":"We employed ATAC sequencing to study chromatin accessibility in adipose tissue perivascular macrophages isolated from wild-type and macrophage-specific KDM6B knockout mice fed a high-fat diet for 5 weeks. This study was designed to identify genotype-dependent changes in accessible chromatin regions associated with KDM6B deficiency during early diet-induced obesity. These data provide insights into regulatory elements controlling macrophage identity, inflammatory activation, lipid-associated macrophage states, and immune remodeling in obese adipose tissue.","dates":{"publication":"2026/09/01"},"accession":"GSE338876","cross_references":{"GSM":["GSM9883971","GSM9883972","GSM9883973","GSM9883974","GSM9883975","GSM9883966","GSM9883967","GSM9883968","GSM9883969","GSM9883970"],"GPL":["24247"],"GSE":["338876"],"taxon":["Mus musculus"]}}