GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE338nnn/GSE338940/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE338940GEOGSEfalseBulk RNA sequencing of whole-blood leukocytes from specific pathogen-free and IMPACT4-exposed miceSpecific pathogen-free laboratory mice exhibit limited immune maturation because of restricted microbial exposure. To determine how exposure to a defined consortium of enteric microbes alters systemic transcriptional programs, whole blood was collected from specific pathogen-free control mice and mice exposed to the IMPACT4 microbial consortium. RNA was extracted from the blood leukocytes and subjected to bulk RNA sequencing. Gene-expression profiles were compared between the two experimental groups to characterize transcriptional programs associated with microbial exposure and systemic immune maturation.2026/08/25GSE338940GSM9885291GSM9885290GSM9885293GSM9885292GSM9885294GSM988528934290338940Mus musculus