{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339052/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339052"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Hepatocyte-derived sIL1RAP restrains chronic inflammation under dietary","description":"Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by hepatic lipid accumulation, injury, inflammation, and fibrosis, but the endogenous hepatocyte-derived secretory signals that restrain hepatic inflammatory responses under dietary stress remain unclear. In this study, bulk RNA sequencing was performed on liver tissues from control mice fed a chow diet, GAN diet-induced MASH mice treated with a control AAV vector, and GAN diet-induced MASH mice treated with hepatocyte-targeted AAV-sIL1RAP. This dataset was designed to characterize GAN diet-induced hepatic transcriptional alterations and to assess whether restoration of hepatocyte-derived soluble interleukin-1 receptor accessory protein (sIL1RAP) attenuates inflammation-associated transcriptional responses. Comparative transcriptomic analysis showed that the GAN diet enhanced inflammatory transcriptional programs, including NF-κB-related signaling, whereas hepatocyte-specific restoration of sIL1RAP mitigated these changes. These data support a role for hepatocyte-derived sIL1RAP in limiting diet-induced hepatic inflammatory responses.","dates":{"publication":"2026/08/13"},"accession":"GSE339052","cross_references":{"GSM":["GSM9887702","GSM9887703","GSM9887706","GSM9887707","GSM9887704","GSM9887705","GSM9887708","GSM9887709","GSM9887710"],"GPL":["28330"],"GSE":["339052"],"taxon":["Mus musculus"]}}