{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339068/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339068"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"A Neutrophil Membrane-Encapsulated Pd/hCeO2 Nanoformulation for Alleviating Age-Dependent Perioperative Neurocognitive Disorders","description":"Perioperative neurocognitive disorder (PND) is a common neurological complication following surgery in elderly individuals and is closely associated with neuroinflammation and blood-brain barrier disruption. In this study, we investigated hippocampal transcriptomic alterations in aged mice subjected to tibial fracture surgery and evaluated the therapeutic effects of a neutrophil membrane-encapsulated Pd/hCeO2 nanoformulation (PCN). Bulk RNA sequencing was performed on hippocampal tissues collected from Control, PND, and PCN-treated mice. Differential gene expression and pathway enrichment analyses were conducted to identify molecular mechanisms involved in surgery-induced neuroinflammation and the therapeutic actions of PCN. These data provide a transcriptomic resource for understanding the pathogenesis of PND and the mechanisms underlying PCN-mediated neuroprotection.","dates":{"publication":"2026/08/31"},"accession":"GSE339068","cross_references":{"GSM":["GSM9887955","GSM9887956","GSM9887953","GSM9887954","GSM9887959","GSM9887949","GSM9887957","GSM9887958","GSM9887962","GSM9887951","GSM9887963","GSM9887952","GSM9887960","GSM9887950","GSM9887961"],"GPL":["28330"],"GSE":["339068"],"taxon":["Mus musculus"]}}