GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339068/primary200OKTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339068GEOGSEfalseA Neutrophil Membrane-Encapsulated Pd/hCeO2 Nanoformulation for Alleviating Age-Dependent Perioperative Neurocognitive DisordersPerioperative neurocognitive disorder (PND) is a common neurological complication following surgery in elderly individuals and is closely associated with neuroinflammation and blood-brain barrier disruption. In this study, we investigated hippocampal transcriptomic alterations in aged mice subjected to tibial fracture surgery and evaluated the therapeutic effects of a neutrophil membrane-encapsulated Pd/hCeO2 nanoformulation (PCN). Bulk RNA sequencing was performed on hippocampal tissues collected from Control, PND, and PCN-treated mice. Differential gene expression and pathway enrichment analyses were conducted to identify molecular mechanisms involved in surgery-induced neuroinflammation and the therapeutic actions of PCN. These data provide a transcriptomic resource for understanding the pathogenesis of PND and the mechanisms underlying PCN-mediated neuroprotection.2026/08/31GSE339068GSM9887955GSM9887956GSM9887953GSM9887954GSM9887959GSM9887949GSM9887957GSM9887958GSM9887951GSM9887962GSM9887963GSM9887952GSM9887960GSM9887950GSM988796128330339068Mus musculus