{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339137/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339137"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Taxus cuspidata extract attenuates allergic airway inflammation, and its constituent taxinine targets the IL-17/TNF program in mast cells","description":"Mast cells are central effectors of IgE-mediated allergic inflammation. To define, transcriptome-wide, how the Taxus cuspidata-derived diterpenoid taxinine modulates mast-cell activation, we profiled bone-marrow-derived mast cells (BMMCs) from C57BL/6 mice in three conditions: untreated control, IgE-sensitized cells stimulated with DNP-BSA (BSA), and DNP-BSA-stimulated cells treated with taxinine. Differential expression, functional enrichment, and gene-set enrichment analysis showed that IgE/antigen stimulation induced a strong inflammatory signature that taxinine partially attenuated, with the IL-17 and TNF signaling programs enriched by stimulation and reciprocally suppressed by taxinine.","dates":{"publication":"2026/07/24"},"accession":"GSE339137","cross_references":{"GSM":["GSM9888978","GSM9888979","GSM9888976","GSM9888977","GSM9888971","GSM9888974","GSM9888975","GSM9888972","GSM9888973"],"GPL":["24247"],"GSE":["339137"],"taxon":["Mus musculus"]}}