{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339192/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Saccharomyces cerevisiae"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339192"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Chaperone condensates buffer the heat shock response against pleiotropic inputs [RNA-seq]","description":"RNA-seq of Saccharomyces cerevisiae profiling the heat shock response (HSR) across chemically distinct stresses and upon acute nuclear depletion of the co-chaperone Sis1. Wild-type cells were profiled unstressed and under heat shock, sodium arsenite, azetidine-2-carboxylic acid (AZC), diazaborine (DZA), and hyperosmotic NaCl, each with and without cycloheximide (CHX) to test translation-dependence. In parallel, a rapamycin-resistant Sis1 anchor-away strain was profiled with and without rapamycin across the same stresses. Only heat shock and, weakly, arsenite induce HSR target genes; nuclear Sis1 buffers HSR output under sub-saturating stress.","dates":{"publication":"2026/08/26"},"accession":"GSE339192","cross_references":{"GSM":["GSM9889919","GSM9889925","GSM9889924","GSM9889923","GSM9889922","GSM9889929","GSM9889928","GSM9889927","GSM9889926","GSM9889961","GSM9889960","GSM9889921","GSM9889920","GSM9889936","GSM9889935","GSM9889934","GSM9889933","GSM9889939","GSM9889938","GSM9889937","GSM9889932","GSM9889931","GSM9889930","GSM9889947","GSM9889946","GSM9889945","GSM9889944","GSM9889949","GSM9889948","GSM9889943","GSM9889942","GSM9889941","GSM9889940","GSM9889909","GSM9889908","GSM9889914","GSM9889958","GSM9889957","GSM9889913","GSM9889912","GSM9889956","GSM9889955","GSM9889911","GSM9889918","GSM9889917","GSM9889916","GSM9889915","GSM9889959","GSM9889950","GSM9889910","GSM9889954","GSM9889953","GSM9889952","GSM9889951"],"GPL":["34739"],"GSE":["339192"],"taxon":["Saccharomyces cerevisiae"],"PMID":["[42619928]"]}}