{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339230/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339230"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Interleukin-1 mediates innate immune signaling and antiviral defense in islets","description":"In this study, the effects of endogenously produced cytokines, following lipopolysaccharide (LPS) administration to mice, on gene expression in islet cells were evaluated by single-cell RNA sequencing (scRNA-seq). Using mice with beta-cell specific Il1r1 deficiency, IL-1 was identified as a primary mediator of changes in β-cell gene expression.","dates":{"publication":"2026/08/23"},"accession":"GSE339230","cross_references":{"GSM":["GSM9891173","GSM9891172","GSM9891175","GSM9891174","GSM9891171","GSM9891170","GSM9891169","GSM9891177","GSM9891166","GSM9891165","GSM9891176","GSM9891168","GSM9891167","GSM9891178"],"GPL":["34290"],"GSE":["339230"],"taxon":["Mus musculus"],"PMID":["[42642325]"]}}