{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339254/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339254"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single cell sequencing of APECED patient and Healthy control peripheral blood cells","description":"10 APECED and 10 Healthy control patients peripheral blood cells isolated for single cell sequencing. scRNA-seq and BCRseq analysis illustrate changes to the composition of the B cell compartment in APECED compared to Healthy control such as a reduction in Naïve B cells and increases to IgM CD27+ CXCR3+ and Class switched atypical B cell subsets with alternative activation (TBX21+ ZEB2+).","dates":{"publication":"2026/07/28"},"accession":"GSE339254","cross_references":{"GSM":["GSM9891962","GSM9891961","GSM9891964","GSM9891963","GSM9891960","GSM9891959","GSM9891958","GSM9891999","GSM9891955","GSM9891954","GSM9891998","GSM9891957","GSM9891956","GSM9891973","GSM9891972","GSM9891975","GSM9891931","GSM9891930","GSM9891974","GSM9891971","GSM9891970","GSM9891969","GSM9891966","GSM9891965","GSM9891968","GSM9891967","GSM9891929","GSM9891984","GSM9891940","GSM9891983","GSM9891942","GSM9891986","GSM9891941","GSM9891985","GSM9891980","GSM9891982","GSM9891981","GSM9891937","GSM9891936","GSM9891939","GSM9891938","GSM9891933","GSM9891977","GSM9891976","GSM9891932","GSM9891979","GSM9891935","GSM9891934","GSM9891978","GSM9892000","GSM9891951","GSM9891995","GSM9891950","GSM9891994","GSM9891953","GSM9891997","GSM9891996","GSM9891952","GSM9891991","GSM9891990","GSM9891993","GSM9892001","GSM9892002","GSM9891992","GSM9891948","GSM9891947","GSM9891949","GSM9891944","GSM9891988","GSM9891987","GSM9891943","GSM9891946","GSM9891945","GSM9891989"],"GPL":["24676"],"GSE":["339254"],"taxon":["Homo sapiens"]}}