GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339254/primaryOK200TranscriptomicsHomo sapiens OtherExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339254GEOGSEfalseSingle cell sequencing of APECED patient and Healthy control peripheral blood cells10 APECED and 10 Healthy control patients peripheral blood cells isolated for single cell sequencing. scRNA-seq and BCRseq analysis illustrate changes to the composition of the B cell compartment in APECED compared to Healthy control such as a reduction in Naïve B cells and increases to IgM CD27+ CXCR3+ and Class switched atypical B cell subsets with alternative activation (TBX21+ ZEB2+).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 sapiens