GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339353/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339353GEOGSEfalseGene expression of adjacent normal liver tissue in China Medical University Hospital (CMUH) cohort of Taiwanese patientsIt’s unknown what, how, and why lipid metabolites involve in cancer prognosis. This study investigated multi-omics measurement in hepatocellular carcinoma (HCC) patient cohort to associate tumoral lipidome, transcriptome, and serological metabolome to disease prognosis. Data indicating that dietary related ether-lipids, e.g., PC O- and PE O-, promote cell mobility and poor prognosis through TRPV2-related cytoskeletal rearrangement. In addition, downregulation of Peroxisome Proliferator-Activated Receptor α (PPARα) and consequential lipophagic deficit increase ether-lipids in cancer cells. Unfortunately, pathological coupling of Very Low-Density Lipoprotein Receptor (VLDLR) overexpression in HCC patients concordantly deteriorates ether-lipid accumulation and facilitates HCC progression via VLDL uptake. Knocking out hepatic VLDLR reduces HCC burden in a spontaneous mouse model. Administration of VLDL-mimicking nanoparticles encapsulating lenvatinib or fenofibrate effectively suppresses tumor progression. This series contains RNA sequencing data generated from adjacent normal liver tissues collected from the same HCC patient cohort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 sapiens