{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339460/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339460"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Fus-depleted oligodendrocytes reduce neuronal damage and Alzheimer’s disease progression in the AppNL-G-F mouse","description":"Oligodendrocytes provide myelination and metabolic support to neurons, but their contribution to Alzheimer's disease (AD) progression remains incompletely understood. To investigate the molecular effects of oligodendrocyte-specific Fus deletion, we performed single-cell RNA sequencing of hippocampal cells from AppNL-G-F (AD), AppNL-G-F/ Fusfl/fl/Cnpcre/+ (AD/cKO), Fusfl/fl/Cnpcre/+ (cKO), and Fusfl/fl (WT) mice. This dataset defines cell type-specific transcriptional profiles of hippocampal cells and identifies transcriptional changes associated with oligodendrocyte-specific Fus deletion in the context of Alzheimer's disease. These data provide a resource for investigating molecular pathways underlying oligodendrocyte function, glial interactions, and Alzheimer's disease pathogenesis.","dates":{"publication":"2026/07/22"},"accession":"GSE339460","cross_references":{"GSM":["GSM9896010"],"GPL":["30172"],"GSE":["339460"],"taxon":["Mus musculus"],"PMID":["[42403013]"]}}