{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE339nnn/GSE339598/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Rattus norvegicus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE339598"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Intravenous Administration of Stromal Vascular Fraction Attenuates Early Busulfan-Induced Testicular Injury in Rats: An Alternative Cell-Based Approach for Spermatogenic Impairment","description":"Chemotherapy can cause lasting damage to the testicles, leading to male infertility. In this study, we tested whether a cell‑based therapy by using a mixture of cells obtained from fat tissue (called stromal vascular fraction, or SVF) could reduce testicular damage in rats treated with busulfan, a chemotherapy drug. We found that giving SVF intravenously immediately after busulfan exposure significantly improved sperm quality and testicular structure within two weeks. Our results suggest that this approach may offer a rapid and practical way to protect against chemotherapy‑induced testicular injury. However, longer‑term studies are needed to confirm whether these early improvements lead to lasting recovery of fertility.","dates":{"publication":"2026/08/19"},"accession":"GSE339598","cross_references":{"GSM":["GSM9898187","GSM9898188"],"GPL":["25947"],"GSE":["339598"],"taxon":["Rattus norvegicus"],"PMID":["[42589179]"]}}