{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE341nnn/GSE341145/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341145"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"7-hydroxycoumarin-β-D-glucuronide protects against cisplatin-induced acute kidney injury via inhibiting p38 MAPK-mediated apoptosis in mice","description":"Cisplatin is a common chemotherapeutic agent limited by severe nephrotoxicity, which easily induces acute kidney injury (AKI) in tumor patients. 7-hydroxycoumarin-β-D-glucuronide (7-HCG), a major kidney-enriched metabolite of coumarins from Hydrangea paniculata, was previously found to accumulate specifically in renal tissue with long elimination half-life. In this study, male C57BL/6 mice were pretreated with 7-HCG at three doses, followed by intraperitoneal cisplatin injection to establish AKI model. Renal tissue mRNA sequencing was performed on control, cisplatin model, 15 mg/kg and 30 mg/kg 7-HCG groups to explore transcriptomic changes. Transcriptome analysis revealed that 7-HCG reversed dysregulated MAPK signaling and apoptosis pathways triggered by cisplatin. Further validation confirmed that 7-HCG reduced renal ROS production, suppressed phosphorylation of p38/ERK/JNK, and downregulated pro-apoptotic proteins Bax and cleaved-caspase3. This dataset provides transcriptomic evidence illustrating the protective mechanism of 7-HCG against cisplatin nephrotoxicity through p38 MAPK/apoptosis axis inhibition. All raw RNA-seq reads and processed gene expression matrices are deposited here for public reuse.","dates":{"publication":"2026/07/28"},"accession":"GSE341145","cross_references":{"GSM":["GSM9900919","GSM9900925","GSM9900914","GSM9900924","GSM9900913","GSM9900923","GSM9900912","GSM9900911","GSM9900922","GSM9900929","GSM9900918","GSM9900928","GSM9900917","GSM9900916","GSM9900927","GSM9900926","GSM9900915","GSM9900921","GSM9900920","GSM9900930"],"GPL":["24247"],"GSE":["341145"],"taxon":["Mus musculus"]}}