GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE341nnn/GSE341363/primaryOK200GenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341363GEOGSEfalseDissecting the cell autonomous and non-autonomous chromatin alterations upon DNMT1 deletion in PV interneuronsThe maturation of cortical networks relies on the precise coordination between excitatory neurons and inhibitory interneurons, whose disruptions underlie the pathophysiology of several neuropsychiatric disorders. Parvalbumin-expressing (PV) interneurons play a key role in modulating cortical excitability and synchronization, making them central to a stable network and proper cognitive function. To better understand the contribution of epigenetic regulation in these processes, we examined the role of DNA methyltransferase 1 (DNMT1) in PV interneurons. By selectively depleting DNMT1 in this population, we aimed to unravel how the absence of DNMT1 impacts the chromatin landscape and, through this, neuronal function, network activity, and mechanisms underlying neuropsychiatric dysfunction.2026/09/14GSE341363GSM9905201GSM990520024247341363Mus musculus