{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE341nnn/GSE341489/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341489"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Hidden outcomes of CRISPR/Cas9 genome editing revealed by targeted sequencing in isogenic human iPSC clones [RNA-seq]","description":"CRISPR/Cas9 editing can create complex on-target alterations that escape conventional PCR genotyping. We characterized ten edited human induced pluripotent stem cell clones derived from four related parental lines carrying a tandem Xq25 duplication encompassing STAG2. Targeted genomic sequencing revealed inversions, plasmid integration, and complex rearrangements and resolved discrepancies between genotyping and transcriptomic observations. This GEO submission provides quantitative genome-browser coverage tracks supporting the transcriptomic and whole-genome analyses. BioProject: PRJNA1499378.","dates":{"publication":"2026/07/30"},"accession":"GSE341489","cross_references":{"GSM":["GSM9907743","GSM9907744","GSM9907741","GSM9907742","GSM9907750","GSM9907749","GSM9907747","GSM9907748","GSM9907745","GSM9907746"],"GPL":["29480"],"GSE":["341489"],"taxon":["Homo sapiens"]}}