GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE341nnn/GSE341834/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341834GEOGSEfalseMAOA+ CAFs enforce immune exclusion in pancreatic cancer by restraining serotonin-dependent histone H3Q5 serotonylationPancreatic ductal adenocarcinoma (PDAC) is characterized by dense desmoplasia and profound T-cell exclusion, yet the stromal metabolic programs that sustain this immune-refractory microenvironment remain poorly understood. Monoamine oxidase A (MAOA) is a mitochondrial enzyme that catalyzes serotonin degradation, but whether this metabolic pathway is co-opted by cancer-associated fibroblasts (CAFs) to regulate antitumor immunity remains unknown.2026/07/29GSE341834GSM9918048GSM9918049GSM9918045GSM9918046GSM9918047GSM991805024247341834Mus musculus