{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342343/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Mus musculus"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342343"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The role of Angiopoietin 1 in acute-on-chronic liver failure","description":"Acute-on-chronic liver failure (ACLF) is an acute liver and multisystem failure in patients with pre-existing liver disease. A common precipitating factor for ACLF is sepsis. Our recent work shows that sepsis-ACLF is associated with loss of Angiopoietin 1 (ANG-1) and endothelial dysfunction that in turn promotes loss of hepatocyte differentiation and liver failure. However, the mechanism of angiopoietin-mediated endothelial to hepatocyte crosstalk in ACLF is not fully understood. We aimed to study Angiopoietin 1-induced changes in liver cells using spatial transcritomics.","dates":{"publication":"2026/09/01"},"accession":"GSE342343","cross_references":{"GSM":["GSM9928801"],"GPL":["33896"],"GSE":["342343"],"taxon":["Mus musculus"]}}