{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342376/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342376"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"The BMP4/BMPRII-BMPRIA axis drives cardiac hypertrophy and fibrosis by cross-regulating cGMP/PKG and p38 pathways","description":"The pathological myocardial hypertrophy and interstitial fibrosis that drive adverse cardiac remodeling are hallmark features of hypertrophic cardiomyopathy and represent a common terminal pathway in various cardiovascular diseases. Bone morphogenetic protein-4 (BMP4) has been implicated in this process, yet its receptor-mediated signaling mechanisms remain incompletely understood. This study aims to elucidate the functional roles of specific BMP receptors—namely BMPRIA and BMPRII—in mediating BMP4-induced pathological cardiac remodeling. Using a combination of transcriptomic profiling in human AC16 cardiomyocytes and validation through pharmacological inhibition, we seek to uncover the downstream signaling pathways responsible for BMP4-driven hypertrophy and fibrosis. The overarching goal is to identify novel receptor-specific therapeutic targets that could enable early intervention or reversal of established cardiac remodeling, potentially through the restoration of cardioprotective cGMP/PKG signaling.","dates":{"publication":"2026/08/30"},"accession":"GSE342376","cross_references":{"GSM":["GSM9929575","GSM9929564","GSM9929574","GSM9929573","GSM9929572","GSM9929568","GSM9929579","GSM9929578","GSM9929567","GSM9929577","GSM9929566","GSM9929565","GSM9929576","GSM9929571","GSM9929581","GSM9929570","GSM9929580","GSM9929569"],"GPL":["24676"],"GSE":["342376"],"taxon":["Homo sapiens"]}}