{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342458/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342458"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Obesity and Diabetes Increase SARS-CoV-2 Susceptibility with Tissue-Specific Immune, Metabolic, and Gut Microbial Dysregulation","description":"Obesity and diabetes are major risk factors for SARS-CoV-2-associated cardiac injury, but the molecular mechanisms underlying increased susceptibility remain incompletely understood. This study generated bulk RNA sequencing data from cardiac tissue collected from 24-week-old male obese diabetic (db/db) and wildtype mice seven days after infection with murine-adapted SARS-CoV-2. Obese diabetic mice exhibited compromised innate and adaptive immune responses, including dysregulated Wnt signaling and impaired IFN-γ activation. These data provide a resource for investigating cardiac-specific transcriptional responses to SARS-CoV-2 infection in the setting of obesity and diabetes.","dates":{"publication":"2026/09/06"},"accession":"GSE342458","cross_references":{"GSM":["GSM9931026","GSM9931025","GSM9931028","GSM9931006","GSM9931027","GSM9931022","GSM9931021","GSM9931024","GSM9931023","GSM9931008","GSM9931007","GSM9931029","GSM9931009","GSM9931020","GSM9931015","GSM9931014","GSM9931017","GSM9931016","GSM9931011","GSM9931010","GSM9931013","GSM9931012","GSM9931019","GSM9931018","GSM9931031","GSM9931030"],"GPL":["34290"],"GSE":["342458"],"taxon":["Mus musculus"]}}