GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342458/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342458GEOGSEfalseObesity and Diabetes Increase SARS-CoV-2 Susceptibility with Tissue-Specific Immune, Metabolic, and Gut Microbial DysregulationObesity and diabetes are major risk factors for SARS-CoV-2-associated cardiac injury, but the molecular mechanisms underlying increased susceptibility remain incompletely understood. This study generated bulk RNA sequencing data from cardiac tissue collected from 24-week-old male obese diabetic (db/db) and wildtype mice seven days after infection with murine-adapted SARS-CoV-2. Obese diabetic mice exhibited compromised innate and adaptive immune responses, including dysregulated Wnt signaling and impaired IFN-γ activation. These data provide a resource for investigating cardiac-specific transcriptional responses to SARS-CoV-2 infection in the setting of obesity and diabetes.2026/09/06GSE342458GSM9931026GSM9931025GSM9931028GSM9931006GSM9931027GSM9931022GSM9931021GSM9931024GSM9931023GSM9931008GSM9931007GSM9931029GSM9931009GSM9931020GSM9931015GSM9931014GSM9931017GSM9931016GSM9931011GSM9931010GSM9931013GSM9931012GSM9931019GSM9931018GSM9931031GSM993103034290342458Mus musculus