{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342646/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342646"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Gene expression profiling of H23 lung adenocarcinoma cells treated with sotorasib and linsitinib alone or in combination","description":"KRAS G12C inhibitors have improved the treatment of KRAS G12C-mutant lung cancer; however, adaptive resistance limits their long-term efficacy. To investigate the transcriptional effects of combined KRAS and IGF1R inhibition, we performed RNA sequencing of the KRAS G12C-mutant lung adenocarcinoma cell line H23 following treatment with sotorasib, linsitinib, or their combination. This dataset provides genome-wide gene expression profiles associated with single-agent and combination treatments and may facilitate the identification of molecular mechanisms underlying the enhanced antitumor effects of combined KRAS and IGF1R inhibition.","dates":{"publication":"2026/08/21"},"accession":"GSE342646","cross_references":{"GSM":["GSM9935369","GSM9935368","GSM9935367","GSM9935366"],"GPL":["34284"],"GSE":["342646"],"taxon":["Homo sapiens"]}}