GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342778/primary200OKOtherHomo sapiensOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342778GEOGSEfalseSpatial transcriptomic profiling of vascular compartments of chronic antibody-mediated rejection in kidney allografts identified compartment-specific signatures: a pilot studyChronic antibody-mediated rejection (CAMR) is a leading cause of late kidney allograft loss, and its vascular compartments are the principal site of injury. To resolve compartment-specific transcriptomic programs, we applied GeoMx Digital Spatial Profiling with the Human NGS Whole Transcriptome Atlas (18,677 targets) to formalin-fixed paraffin-embedded kidney allograft biopsies. Forty-eight regions of interest (ROIs) were profiled across three vascular compartments (glomerulus, peritubular capillary, and vessel) in patients with CAMR or no evidence of rejection (NER), stratified by donor-specific antibody (DSA) status, together with normal (non-transplant) kidney as a control. As a pilot study with one patient per group, this dataset is intended to be descriptive and hypothesis-generating rather than definitive.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 sapiens