GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342815/primary200OKTranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342815GEOGSEfalseTLR7 Agonist Nanomedicine Suppresses Lung Metastasis of Osteosarcoma by Remodeling the Immune MicroenvironmentThis study aimed to evaluate a TLR7 agonist liposome (1V209-Cho-Lip) for its anti-metastatic effects and mechanisms in osteosarcoma. Single-cell transcriptomics analysis demonstrated that treatment with 1V209-Cho-Lip alleviates myeloid-mediated immunosuppression, promotes CD8+ T cell activation and clonal expansion, and improves intercellular communication between tumor cells and immune cells.2026/08/12GSE342815GSM9940080GSM994008124247342815Mus musculus