{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342881/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342881"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic signatures induced by single versus dual lipoparticle-formulated adjuvants","description":"Adjuvant delivery using lipid-polymer hybrid nanoparticles (Lipoparticles) represents a promising strategy to modulate immune cell activation. This study investigates whether the combination of two adjuvants encapsulated within Lipoparticles induces distinct transcriptional responses compared with individual adjuvant formulations. Bone marrow-derived macrophages (BMDMs) generated from five independent mice were treated with single or dual adjuvant formulations, and RNA sequencing was performed to characterize genome-wide gene expression changes. Differential gene expression and functional enrichment analyses were conducted to identify biological pathways modulated by these formulations, with a particular focus on immune-related responses.","dates":{"publication":"2026/08/14"},"accession":"GSE342881","cross_references":{"GSM":["GSM9941390","GSM9941380","GSM9941391","GSM9941392","GSM9941381","GSM9941393","GSM9941382","GSM9941398","GSM9941387","GSM9941388","GSM9941389","GSM9941379","GSM9941383","GSM9941394","GSM9941395","GSM9941384","GSM9941396","GSM9941385","GSM9941386","GSM9941397"],"GPL":["24247"],"GSE":["342881"],"taxon":["Mus musculus"]}}