GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342881/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342881GEOGSEfalseTranscriptomic signatures induced by single versus dual lipoparticle-formulated adjuvantsAdjuvant delivery using lipid-polymer hybrid nanoparticles (Lipoparticles) represents a promising strategy to modulate immune cell activation. This study investigates whether the combination of two adjuvants encapsulated within Lipoparticles induces distinct transcriptional responses compared with individual adjuvant formulations. Bone marrow-derived macrophages (BMDMs) generated from five independent mice were treated with single or dual adjuvant formulations, and RNA sequencing was performed to characterize genome-wide gene expression changes. Differential gene expression and functional enrichment analyses were conducted to identify biological pathways modulated by these formulations, with a particular focus on immune-related responses.2026/08/14GSE342881GSM9941390GSM9941380GSM9941391GSM9941392GSM9941381GSM9941393GSM9941382GSM9941398GSM9941387GSM9941388GSM9941389GSM9941379GSM9941383GSM9941394GSM9941395GSM9941384GSM9941385GSM9941396GSM9941386GSM994139724247342881Mus musculus