{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342939/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":[" Expression profiling by high throughput sequencing","Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342939"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Senescent activated naive B cells promote anti-citrullinated antigen T cell responses and the transition to clinical rheumatoid arthritis","description":"This study profiles peripheral B cells from individuals at risk for rheumatoid arthritis (RA), including ACPA-positive converters to clinical RA, ACPA-positive non-converters, and healthy controls, at paired pre and post time points. Using 10x Genomics Chromium single-cell gene expression (scRNA-seq), antibody-derived tag / CITE-seq surface protein profiling, and B cell receptor (BCR) V(D)J sequencing, we characterize activated naive B cell states associated with progression toward clinical RA.","dates":{"publication":"2026/08/07"},"accession":"GSE342939","cross_references":{"GSM":["GSM9943450","GSM9943412","GSM9943456","GSM9943411","GSM9943455","GSM9943414","GSM9943458","GSM9943457","GSM9943413","GSM9943452","GSM9943451","GSM9943454","GSM9943410","GSM9943453","GSM9943419","GSM9943416","GSM9943415","GSM9943459","GSM9943418","GSM9943417","GSM9943461","GSM9943460","GSM9943423","GSM9943467","GSM9943466","GSM9943422","GSM9943469","GSM9943425","GSM9943424","GSM9943468","GSM9943463","GSM9943462","GSM9943421","GSM9943465","GSM9943420","GSM9943464","GSM9943427","GSM9943426","GSM9943429","GSM9943428","GSM9943470","GSM9943472","GSM9943471","GSM9943434","GSM9943478","GSM9943477","GSM9943433","GSM9943436","GSM9943435","GSM9943479","GSM9943474","GSM9943430","GSM9943473","GSM9943432","GSM9943476","GSM9943431","GSM9943475","GSM9943438","GSM9943437","GSM9943439","GSM9943481","GSM9943480","GSM9943445","GSM9943444","GSM9943447","GSM9943446","GSM9943441","GSM9943440","GSM9943443","GSM9943442","GSM9943409","GSM9943408","GSM9943449","GSM9943405","GSM9943404","GSM9943448","GSM9943407","GSM9943406"],"GPL":["34284"],"GSE":["342939"],"taxon":["Homo sapiens"]}}