GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342939/primaryOK200OtherHomo sapiens Expression profiling by high throughput sequencingOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342939GEOGSEfalseSenescent activated naive B cells promote anti-citrullinated antigen T cell responses and the transition to clinical rheumatoid arthritisThis study profiles peripheral B cells from individuals at risk for rheumatoid arthritis (RA), including ACPA-positive converters to clinical RA, ACPA-positive non-converters, and healthy controls, at paired pre and post time points. Using 10x Genomics Chromium single-cell gene expression (scRNA-seq), antibody-derived tag / CITE-seq surface protein profiling, and B cell receptor (BCR) V(D)J sequencing, we characterize activated naive B cell states associated with progression toward clinical RA.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 sapiens