{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342977/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342977"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional consequences of viral and cellular ORF overexpression in hTERT-RPE1 cells","description":"To define the transcriptional programs driven by individual viral and cellular open reading frames, hTERT-RPE1 cells were stably transduced with lentiviral constructs expressing GFP11 (negative control), the human papillomavirus E7 oncoprotein, the Epstein-Barr virus protein BNLF2b, or the cAMP-dependent protein kinase inhibitor alpha (PKIA). After puromycin selection, total RNA was profiled by 3' end counting RNA-seq in four biological replicates per condition. Comparison of each ORF-expressing population against the GFP11 control defines the gene expression changes attributable to that ORF.","dates":{"publication":"2026/08/13"},"accession":"GSE342977","cross_references":{"GSM":["GSM9944295","GSM9944294","GSM9944297","GSM9944296","GSM9944291","GSM9944290","GSM9944293","GSM9944292","GSM9944302","GSM9944299","GSM9944288","GSM9944287","GSM9944298","GSM9944301","GSM9944300","GSM9944289"],"GPL":["34284"],"GSE":["342977"],"taxon":["Homo sapiens"]}}