{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343063/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343063"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Spatially Resolved Cell-Cell Communication in Small Cell Lung Cancer Reveals Macrophage-Driven Immune Evasion Programs","description":"Small cell lung cancer (SCLC) exhibits poor responses to immunotherapy despite abundant immune infiltration. We performed single-cell spatial transcriptomic profiling of more than 2.5 million cells from six surgically resected limited-stage SCLC tumors using the 10x Genomics Xenium In Situ platform (5K Human Pan Tissue & Pathways Panel). Spatially resolved cell-cell communication analysis identified macrophages as the dominant communicating immune population and revealed distinct spatial macrophage states associated with differential T-cell phenotypes and immune evasion programs.","dates":{"publication":"2026/08/18"},"accession":"GSE343063","cross_references":{"GSM":["GSM9945416","GSM9945415","GSM9945420","GSM9945418","GSM9945417","GSM9945419"],"GPL":["33762"],"GSE":["343063"],"taxon":["Homo sapiens"]}}