GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343063/primaryOK200OtherHomo sapiensOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343063GEOGSEfalseSpatially Resolved Cell-Cell Communication in Small Cell Lung Cancer Reveals Macrophage-Driven Immune Evasion ProgramsSmall cell lung cancer (SCLC) exhibits poor responses to immunotherapy despite abundant immune infiltration. We performed single-cell spatial transcriptomic profiling of more than 2.5 million cells from six surgically resected limited-stage SCLC tumors using the 10x Genomics Xenium In Situ platform (5K Human Pan Tissue & Pathways Panel). Spatially resolved cell-cell communication analysis identified macrophages as the dominant communicating immune population and revealed distinct spatial macrophage states associated with differential T-cell phenotypes and immune evasion programs.2026/08/18GSE343063GSM9945416GSM9945415GSM9945420GSM9945418GSM9945417GSM994541933762343063Homo sapiens