{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343367/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343367"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"JAX scRNAseq Study01- Single-cell RNA sequencing of male KOLF2.2J hiPSC-derived cortical brain organoids homozygous null for PAX6","description":"This study characterizes the transcriptional dynamics underlying cortical brain organoid development in the absence of the transcription factor PAX6. A PAX6 null allele was engineered by introducing a premature termination codon causing a frameshift mutation (PTC+1). Single-cell RNA sequencing (scRNA-seq) was performed on samples collected at days 7, 8, and 9 following the initiation of differentiation from human induced pluripotent stem cells (hiPSCs), enabling a detailed temporal analysis of gene expression changes.","dates":{"publication":"2026/08/12"},"accession":"GSE343367","cross_references":{"GSM":["GSM9949787","GSM9949786"],"GPL":["34284"],"GSE":["343367"],"taxon":["Homo sapiens"]}}