GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343368/primaryOK200GenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343368GEOGSEfalseNWU Study 2- ATAC-seq timecourse of KOLF2.2J hiPSC after Auxin-induced protein degradation of specific gene productsThis study investigates the impact of gene products on chromatin accessibility in growing hiPSC at 0, 6 & 24 hours after acute protein depletion. Crispr editing was used to add an auxin-dependent degron to the C-termini of gene products expressed from the endogeneous loci and to insert an auxin-responsive degradation E3 ligase to the AAVS locus. Rapid (<30 min), specific target protein degradation in KOLF2.2J hiPSCs was induced by a synthetic auxin derivative (5-Ad-IAA) and bulk ATAC-seq was performed at timepoints to define early (6 hr) and later (24 hr) downstream chromatin remodeling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 sapiens