{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343570/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343570"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Pembrolizumab with or without vorinostat in first-line metastatic non-small cell lung cancer: a randomized phase 2 trial","description":"Bulk RNA sequencing was performed on fresh-frozen tumor biopsies collected from patients with treatment-naïve metastatic non-small cell lung cancer (NSCLC) enrolled in a randomized phase II clinical trial comparing pembrolizumab monotherapy with pembrolizumab plus the histone deacetylase inhibitor vorinostat. Tumor biopsies were obtained before treatment and during cycle 1 (days 14–21) to characterize treatment-induced transcriptional changes associated with PD-1 blockade alone or in combination with HDAC inhibition.","dates":{"publication":"2026/09/22"},"accession":"GSE343570","cross_references":{"GSM":["GSM9957535","GSM9957536","GSM9957537","GSM9957538","GSM9957531","GSM9957498","GSM9957532","GSM9957499","GSM9957533","GSM9957534","GSM9957539","GSM9957494","GSM9957495","GSM9957496","GSM9957497","GSM9957530","GSM9957490","GSM9957491","GSM9957492","GSM9957493","GSM9957546","GSM9957502","GSM9957503","GSM9957504","GSM9957505","GSM9957542","GSM9957543","GSM9957500","GSM9957501","GSM9957545","GSM9957506","GSM9957507","GSM9957508","GSM9957509","GSM9957540","GSM9957541","GSM9957513","GSM9957514","GSM9957515","GSM9957516","GSM9957510","GSM9957511","GSM9957512","GSM9957479","GSM9957517","GSM9957518","GSM9957519","GSM9957524","GSM9957525","GSM9957526","GSM9957527","GSM9957520","GSM9957487","GSM9957488","GSM9957521","GSM9957489","GSM9957522","GSM9957523","GSM9957528","GSM9957529","GSM9957483","GSM9957484","GSM9957485","GSM9957486","GSM9957480","GSM9957481","GSM9957482"],"GPL":["30173"],"GSE":["343570"],"taxon":["Homo sapiens"]}}