{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343588/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343588"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Effect of imatinib on cisplatin-induced nephrotoxicity in mice","description":"Cisplatin is a chemotherapeutic agent that induces proximal tubule injury in the kidneys. We aimed at exploring the effect of imatinib, a Tyrosine Kinase Inhibitor (THI), on the entry of cisplatin in proximal tubular cells and on cisplatin-induced DNA damage. RNA sequencing was performed in whole kidneys of mice (control groupe, n=4, 20mg/kg cisplatin-treated mice, n=4, 20mg/kg cisplatin + 150mg/kg imatinib-treated mice, n=4), which were collected 3 days after cisplatin intraperitoneal injection. In the cisplatin + imatinib group, imatinib was injected the day before cisplatin injection, and every day until the mice were euthanized.","dates":{"publication":"2026/08/17"},"accession":"GSE343588","cross_references":{"GSM":["GSM9957843","GSM9957844","GSM9957845","GSM9957846","GSM9957840","GSM9957841","GSM9957842","GSM9957847","GSM9957848","GSM9957849","GSM9957838","GSM9957839"],"GPL":["30172"],"GSE":["343588"],"taxon":["Mus musculus"]}}