GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343588/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343588GEOGSEfalseEffect of imatinib on cisplatin-induced nephrotoxicity in miceCisplatin is a chemotherapeutic agent that induces proximal tubule injury in the kidneys. We aimed at exploring the effect of imatinib, a Tyrosine Kinase Inhibitor (THI), on the entry of cisplatin in proximal tubular cells and on cisplatin-induced DNA damage. RNA sequencing was performed in whole kidneys of mice (control groupe, n=4, 20mg/kg cisplatin-treated mice, n=4, 20mg/kg cisplatin + 150mg/kg imatinib-treated mice, n=4), which were collected 3 days after cisplatin intraperitoneal injection. In the cisplatin + imatinib group, imatinib was injected the day before cisplatin injection, and every day until the mice were euthanized.2026/08/17GSE343588GSM9957843GSM9957844GSM9957845GSM9957846GSM9957840GSM9957841GSM9957842GSM9957847GSM9957848GSM9957849GSM9957838GSM995783930172343588Mus musculus