{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343732/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343732"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Native American ancestry-enriched eQTLs regulate HER2 amplicon genes and are associated with breast cancer outcomes in Colombian women","description":"Women with higher Native American (NA) ancestry are more likely to develop HER2-positive breast tumors and exhibit increased ERBB2 expression. We performed RNA sequencing of tumor and adjacent non-tumoral breast tissue from Colombian women with invasive breast cancer. Germline genotypes were obtained from RNA-seq data using the GATK4 pipeline. Local ancestry was inferred with RFMix. eQTL analyses identified trans-eQTLs rs77910576 (7p21.1) and rs12144827 (1p13.3) associated with increased expression of HER2 amplicon genes, supporting a role for ancestry-specific regulatory variation in shaping breast cancer biology.","dates":{"publication":"2026/08/17"},"accession":"GSE343732","cross_references":{"GSM":["GSM9961280","GSM9961160","GSM9961281","GSM9961161","GSM9961282","GSM9961040","GSM9961041","GSM9961162","GSM9961283","GSM9961042","GSM9961163","GSM9961284","GSM9961164","GSM9961285","GSM9961043","GSM9961044","GSM9961165","GSM9961286","GSM9961287","GSM9961045","GSM9961166","GSM9961167","GSM9961288","GSM9961046","GSM9961047","GSM9961289","GSM9961168","GSM9961048","GSM9961169","GSM9961049","GSM9961270","GSM9961150","GSM9961271","GSM9961030","GSM9961151","GSM9961272","GSM9961273","GSM9961031","GSM9961152","GSM9961153","GSM9961274","GSM9961032","GSM9961154","GSM9961033","GSM9961275","GSM9961276","GSM9961034","GSM9961155","GSM9961156","GSM9961035","GSM9961277","GSM9961157","GSM9961036","GSM9961278","GSM9961279","GSM9961037","GSM9961158","GSM9961038","GSM9961159","GSM9961039","GSM9961260","GSM9961140","GSM9961261","GSM9961141","GSM9961262","GSM9961020","GSM9961021","GSM9961263","GSM9961142","GSM9961022","GSM9961143","GSM9961264","GSM9961144","GSM9961265","GSM9961023","GSM9961024","GSM9961266","GSM9961145","GSM9961267","GSM9961025","GSM9961146","GSM9961147","GSM9961268","GSM9961026","GSM9961027","GSM9961148","GSM9961269","GSM9961028","GSM9961149","GSM9961029","GSM9961250","GSM9961130","GSM9961251","GSM9961010","GSM9961131","GSM9961252","GSM9961253","GSM9961011","GSM9961132","GSM9961133","GSM9961254","GSM9961012","GSM9961013","GSM9961134","GSM9961255","GSM9961256","GSM9961014","GSM9961135","GSM9961136","GSM9961257","GSM9961015","GSM9961016","GSM9961137","GSM9961258","GSM9961259","GSM9961138","GSM9961017","GSM9961018","GSM9961139","GSM9961019","GSM9961240","GSM9961120","GSM9961241","GSM9961121","GSM9961242","GSM9961122","GSM9961243","GSM9961244","GSM9961123","GSM9961124","GSM9961245","GSM9961125","GSM9961246","GSM9961247","GSM9961126","GSM9961127","GSM9961248","GSM9961128","GSM9961007","GSM9961249","GSM9961008","GSM9961129","GSM9961009","GSM9961350","GSM9961230","GSM9961351","GSM9961110","GSM9961231","GSM9961111","GSM9961232","GSM9961233","GSM9961112","GSM9961113","GSM9961234","GSM9961114","GSM9961235","GSM9961236","GSM9961115","GSM9961237","GSM9961116","GSM9961117","GSM9961238","GSM9961239","GSM9961118","GSM9961119","GSM9961340","GSM9961220","GSM9961341","GSM9961342","GSM9961221","GSM9961100","GSM9961101","GSM9961222","GSM9961343","GSM9961102","GSM9961223","GSM9961344","GSM9961224","GSM9961345","GSM9961103","GSM9961104","GSM9961225","GSM9961346","GSM9961105","GSM9961226","GSM9961347","GSM9961227","GSM9961106","GSM9961348","GSM9961107","GSM9961228","GSM9961349","GSM9961108","GSM9961229","GSM9961109","GSM9961330","GSM9961210","GSM9961331","GSM9961211","GSM9961332","GSM9961333","GSM9961212","GSM9961213","GSM9961334","GSM9961214","GSM9961335","GSM9961336","GSM9961215","GSM9961216","GSM9961337","GSM9961217","GSM9961338","GSM9961339","GSM9961218","GSM9961219","GSM9961320","GSM9961321","GSM9961200","GSM9961322","GSM9961201","GSM9961202","GSM9961323","GSM9961324","GSM9961203","GSM9961204","GSM9961325","GSM9961205","GSM9961326","GSM9961327","GSM9961206","GSM9961207","GSM9961328","GSM9961208","GSM9961329","GSM9961209","GSM9961309","GSM9961310","GSM9961311","GSM9961312","GSM9961313","GSM9961314","GSM9961315","GSM9961316","GSM9961317","GSM9961318","GSM9961319","GSM9961300","GSM9961301","GSM9961302","GSM9961303","GSM9961304","GSM9961305","GSM9961306","GSM9961307","GSM9961308","GSM9961090","GSM9961091","GSM9961092","GSM9961093","GSM9961094","GSM9961095","GSM9961096","GSM9961097","GSM9961098","GSM9961099","GSM9961080","GSM9961081","GSM9961082","GSM9961083","GSM9961084","GSM9961085","GSM9961086","GSM9961087","GSM9961088","GSM9961089","GSM9961190","GSM9961070","GSM9961191","GSM9961192","GSM9961071","GSM9961193","GSM9961072","GSM9961073","GSM9961194","GSM9961074","GSM9961195","GSM9961196","GSM9961075","GSM9961076","GSM9961197","GSM9961077","GSM9961198","GSM9961078","GSM9961199","GSM9961079","GSM9961180","GSM9961060","GSM9961181","GSM9961061","GSM9961182","GSM9961183","GSM9961062","GSM9961184","GSM9961063","GSM9961064","GSM9961185","GSM9961186","GSM9961065","GSM9961187","GSM9961066","GSM9961067","GSM9961188","GSM9961189","GSM9961068","GSM9961069","GSM9961290","GSM9961170","GSM9961291","GSM9961050","GSM9961171","GSM9961292","GSM9961293","GSM9961051","GSM9961172","GSM9961173","GSM9961294","GSM9961052","GSM9961053","GSM9961295","GSM9961174","GSM9961296","GSM9961054","GSM9961175","GSM9961176","GSM9961297","GSM9961055","GSM9961056","GSM9961298","GSM9961177","GSM9961299","GSM9961057","GSM9961178","GSM9961058","GSM9961179","GSM9961059"],"GPL":["28038"],"GSE":["343732"],"taxon":["Homo sapiens"]}}