GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343732/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343732GEOGSEfalseNative American ancestry-enriched eQTLs regulate HER2 amplicon genes and are associated with breast cancer outcomes in Colombian womenWomen with higher Native American (NA) ancestry are more likely to develop HER2-positive breast tumors and exhibit increased ERBB2 expression. We performed RNA sequencing of tumor and adjacent non-tumoral breast tissue from Colombian women with invasive breast cancer. Germline genotypes were obtained from RNA-seq data using the GATK4 pipeline. Local ancestry was inferred with RFMix. eQTL analyses identified trans-eQTLs rs77910576 (7p21.1) and rs12144827 (1p13.3) associated with increased expression of HER2 amplicon genes, supporting a role for ancestry-specific regulatory variation in shaping breast cancer biology.2026/08/17GSE343732GSM9961280GSM9961160GSM9961281GSM9961161GSM9961282GSM9961040GSM9961041GSM9961162GSM9961283GSM9961042GSM9961163GSM9961284GSM9961164GSM9961285GSM9961043GSM9961044GSM9961165GSM9961286GSM9961287GSM9961045GSM9961166GSM9961167GSM9961288GSM9961046GSM9961047GSM9961168GSM9961289GSM9961048GSM9961169GSM9961049GSM9961270GSM9961150GSM9961271GSM9961030GSM9961151GSM9961272GSM9961273GSM9961031GSM9961152GSM9961153GSM9961274GSM9961032GSM9961033GSM9961154GSM9961275GSM9961276GSM9961034GSM9961155GSM9961156GSM9961277GSM9961035GSM9961036GSM9961157GSM9961278GSM9961279GSM9961037GSM9961158GSM9961038GSM9961159GSM9961039GSM9961260GSM9961140GSM9961261GSM9961141GSM9961262GSM9961020GSM9961021GSM9961142GSM9961263GSM9961022GSM9961143GSM9961264GSM9961144GSM9961265GSM9961023GSM9961024GSM9961145GSM9961266GSM9961267GSM9961025GSM9961146GSM9961147GSM9961268GSM9961026GSM9961027GSM9961148GSM9961269GSM9961028GSM9961149GSM9961029GSM9961250GSM9961130GSM9961251GSM9961010GSM9961131GSM9961252GSM9961253GSM9961011GSM9961132GSM9961133GSM9961254GSM9961012GSM9961013GSM9961134GSM9961255GSM9961256GSM9961014GSM9961135GSM9961136GSM9961257GSM9961015GSM9961016GSM9961137GSM9961258GSM9961259GSM9961017GSM9961138GSM9961018GSM9961139GSM9961019GSM9961240GSM9961120GSM9961241GSM9961121GSM9961242GSM9961122GSM9961243GSM9961123GSM9961244GSM9961124GSM9961245GSM9961125GSM9961246GSM9961247GSM9961126GSM9961127GSM9961248GSM9961007GSM9961128GSM9961249GSM9961008GSM9961129GSM9961009GSM9961350GSM9961230GSM9961351GSM9961110GSM9961231GSM9961111GSM9961232GSM9961233GSM9961112GSM9961113GSM9961234GSM9961114GSM9961235GSM9961236GSM9961115GSM9961116GSM9961237GSM9961117GSM9961238GSM9961239GSM9961118GSM9961119GSM9961340GSM9961220GSM9961341GSM9961342GSM9961100GSM9961221GSM9961101GSM9961222GSM9961343GSM9961102GSM9961223GSM9961344GSM9961224GSM9961345GSM9961103GSM9961104GSM9961225GSM9961346GSM9961105GSM9961226GSM9961347GSM9961227GSM9961348GSM9961106GSM9961107GSM9961228GSM9961349GSM9961108GSM9961229GSM9961109GSM9961330GSM9961210GSM9961331GSM9961211GSM9961332GSM9961333GSM9961212GSM9961213GSM9961334GSM9961214GSM9961335GSM9961336GSM9961215GSM9961216GSM9961337GSM9961217GSM9961338GSM9961339GSM9961218GSM9961219GSM9961320GSM9961200GSM9961321GSM9961322GSM9961201GSM9961202GSM9961323GSM9961203GSM9961324GSM9961204GSM9961325GSM9961205GSM9961326GSM9961206GSM9961327GSM9961207GSM9961328GSM9961208GSM9961329GSM9961209GSM9961309GSM9961310GSM9961311GSM9961312GSM9961313GSM9961314GSM9961315GSM9961316GSM9961317GSM9961318GSM9961319GSM9961300GSM9961301GSM9961302GSM9961303GSM9961304GSM9961305GSM9961306GSM9961307GSM9961308GSM9961090GSM9961091GSM9961092GSM9961093GSM9961094GSM9961095GSM9961096GSM9961097GSM9961098GSM9961099GSM9961080GSM9961081GSM9961082GSM9961083GSM9961084GSM9961085GSM9961086GSM9961087GSM9961088GSM9961089GSM9961190GSM9961070GSM9961191GSM9961071GSM9961192GSM9961193GSM9961072GSM9961073GSM9961194GSM9961074GSM9961195GSM9961196GSM9961075GSM9961076GSM9961197GSM9961077GSM9961198GSM9961078GSM9961199GSM9961079GSM9961180GSM9961060GSM9961181GSM9961061GSM9961182GSM9961062GSM9961183GSM9961184GSM9961063GSM9961064GSM9961185GSM9961065GSM9961186GSM9961187GSM9961066GSM9961067GSM9961188GSM9961068GSM9961189GSM9961069GSM9961290GSM9961170GSM9961291GSM9961050GSM9961171GSM9961292GSM9961293GSM9961051GSM9961172GSM9961173GSM9961294GSM9961052GSM9961053GSM9961174GSM9961295GSM9961296GSM9961054GSM9961175GSM9961176GSM9961297GSM9961055GSM9961056GSM9961177GSM9961298GSM9961299GSM9961057GSM9961178GSM9961058GSM9961179GSM996105928038343732Homo sapiens