{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343966/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343966"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-Cell Transcriptomic Profiling of Immune Cells from Parental and EMP1-Deficient MB49 Bladder Tumors.","description":"In this study, we employed a single-cell RNA sequencing (scRNA-seq) approach using the 10x Genomics platform to investigate the immune microenvironment of syngeneic mouse bladder tumors. Tumors were established in immunocompetent C57BL/6 mice using parental or EMP1-knockout MB49 bladder cancer cells. Tumor-infiltrating immune cells were isolated and profiled at single-cell resolution to define immune cell populations, transcriptional states, and functional programs within the tumor microenvironment. Comparative analyses were performed to determine how tumor-cell EMP1 expression influences immune cell composition, activation and exhaustion states, inflammatory signaling, and intercellular communication. This dataset provides a single-cell transcriptomic resource for investigating EMP1-mediated regulation of antitumor immunity in bladder cancer.","dates":{"publication":"2026/08/20"},"accession":"GSE343966","cross_references":{"GSM":["GSM9965743","GSM9965744"],"GPL":["34290"],"GSE":["343966"],"taxon":["Mus musculus"]}}