{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344216/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344216"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-nucleus transcriptomics reveals coordinated neuronal, immune, and glial dysregulation in the dorsolateral prefrontal cortex in major depressive disorder","description":"We used single-nucleus RNA sequencing to define cell-type-specific molecular alterations in the dorsolateral prefrontal cortex (dlPFC) of individuals with MDD. We assessed cell-type composition, differential expression, pathway enrichment, oligodendrocyte-lineage pseudotime, ligand-receptor communication, transcription-factor regulon activity, and overlap with MDD-linked genetic variants. The integrated atlas resolved excitatory and inhibitory neuronal subclasses, oligodendrocyte-lineage cells, astrocytes, microglia/perivascular macrophages, endothelial cells, and vascular-associated populations.","dates":{"publication":"2026/08/24"},"accession":"GSE344216","cross_references":{"GSM":["GSM9973084","GSM9973083","GSM9973082","GSM9973081","GSM9973080","GSM9973109","GSM9973108","GSM9973107","GSM9973106","GSM9973105","GSM9973104","GSM9973103","GSM9973069","GSM9973102","GSM9973101","GSM9973100","GSM9973089","GSM9973088","GSM9973087","GSM9973086","GSM9973085","GSM9973095","GSM9973073","GSM9973072","GSM9973094","GSM9973093","GSM9973071","GSM9973092","GSM9973070","GSM9973091","GSM9973090","GSM9973114","GSM9973113","GSM9973112","GSM9973079","GSM9973078","GSM9973111","GSM9973077","GSM9973110","GSM9973099","GSM9973098","GSM9973076","GSM9973075","GSM9973097","GSM9973074","GSM9973096"],"GPL":["24676"],"GSE":["344216"],"taxon":["Homo sapiens"]}}